mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor...
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| Format: | Article |
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Elsevier
2018
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| Online Access: | http://hdl.handle.net/1721.1/118941 https://orcid.org/0000-0003-4642-3706 https://orcid.org/0000-0002-9535-7664 https://orcid.org/0000-0002-7043-5013 https://orcid.org/0000-0002-8206-8003 https://orcid.org/0000-0002-6702-4192 https://orcid.org/0000-0002-1446-7256 |