Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo

Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo

mRNA has broad potential for treating diseases requiring protein expression. However, mRNA can also induce an immune response with associated toxicity. Replacement of uridine bases with pseudouridine has been postulated to modulate both mRNA immunogenicity and potency. Here, we explore the immune re...

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Bibliographic Details
Main Authors: Heartlein, Michael W., DeRosa, Frank, Kauffman, Kevin John, Mir, Faryal, Jhunjhunwala, Siddharth, Kaczmarek, James Cliff, Hurtado, Juan E., Yang, Jung H, Webber, Matthew, Kowalski, Piotr S, Anderson, Daniel Griffith
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/119489
https://orcid.org/0000-0002-9436-2453
https://orcid.org/0000-0001-8046-2288
https://orcid.org/0000-0002-6516-7499
https://orcid.org/0000-0003-0624-3532
https://orcid.org/0000-0001-8607-0189
https://orcid.org/0000-0001-5629-4798

Internet

http://hdl.handle.net/1721.1/119489
https://orcid.org/0000-0002-9436-2453
https://orcid.org/0000-0001-8046-2288
https://orcid.org/0000-0002-6516-7499
https://orcid.org/0000-0003-0624-3532
https://orcid.org/0000-0001-8607-0189
https://orcid.org/0000-0001-5629-4798

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