Lifestyle modifications: coordinating the tRNA epitranscriptome with codon bias to adapt translation during stress responses

Cells adapt to stress by altering gene expression at multiple levels. Here, we propose a new mechanism regulating stress-dependent gene expression at the level of translation, with coordinated interplay between the tRNA epitranscriptome and biased codon usage in families of stress-response genes. In...

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Bibliographic Details
Main Authors: Chan, Cheryl, Begley, Thomas J., Pham, Phuong M., Dedon, Peter C
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Biomed Central Ltd 2019
Online Access:http://hdl.handle.net/1721.1/119843
https://orcid.org/0000-0003-0011-3067