Radiation-enhanced delivery of systemically administered amphiphilic-CpG oligodeoxynucleotide

Along with vaccines and checkpoint blockade, immune adjuvants may have an important role in tumor immunotherapy. Oligodeoxynucleotides containing unmethylated cytidyl guanosyl dinucleotide motifs (CpG ODN) are TLR9 ligands with attractive immunostimulatory properties, but intratumoral administration...

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Bibliographic Details
Main Authors: Appelbe, Oliver K., Flor, Amy, Rymut, Nick, Kron, Stephen J., Moynihan, Kelly Dare, Irvine, Darrell J
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Elsevier 2019
Online Access:http://hdl.handle.net/1721.1/119865