Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin

Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin

BACKGROUND A subset of trauma patients undergo fibrinolysis shutdown rather than pathologic hyperfibrinolysis, contributing to organ failure. The molecular basis for fibrinolysis shutdown in trauma is incompletely understood. Elastase released from primed/activated human neutrophils (HNE) has histor...

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Bibliographic Details
Main Authors: Moore, Hunter B., Banerjee, Anirban, Silliman, Christopher C., Moore, Ernest E., Barrett, Christopher D, Yaffe, Michael B
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Published: Ovid Technologies (Wolters Kluwer Health) 2019
Online Access:http://hdl.handle.net/1721.1/119876
https://orcid.org/0000-0001-9720-8155
https://orcid.org/0000-0002-9547-3251

Internet

http://hdl.handle.net/1721.1/119876
https://orcid.org/0000-0001-9720-8155
https://orcid.org/0000-0002-9547-3251

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