3D-resolved targeting of photodynamic therapy using temporal focusing

A method for selectively inducing apoptosis in tumor nodules is presented, with close-to-cellular level resolution, using 3D-resolved widefield temporal focusing illumination. Treatment times on the order of seconds were achieved using Verteporfin as the photosensitizer, with doses of 30 μg ml-1and...

Full description

Bibliographic Details
Main Authors: Klein, Oliver, Evans, Conor L, Rowlands, Christopher, Wu, Jacqueline J, Uzel, Sebastien GM, So, Peter T. C.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Wiley Blackwell 2019
Online Access:http://hdl.handle.net/1721.1/120074
https://orcid.org/0000-0002-8261-2371
https://orcid.org/0000-0003-4698-6488