Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding

Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding

Ectodomain shedding of cell-surface precursor proteins by metalloproteases generates important cellular signalingmolecules. Of importance for disease is the release of ligands that activate the EGFR, such as TGFα, which is mostly carried out by ADAM17 [a member of the A-disintegrin and metalloprotea...

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Bibliographic Details
Main Authors: Kefaloyianni, Eirini, Harrison, Christina, Sabbisetti, Venkata S., Herrlich, Andreas, Wilson, Jennifer Lynn, Stopfer, Lauren Elizabeth, Fraenkel, Ernest, Lauffenburger, Douglas A
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: American Association for Cancer Research (AACR) 2019
Online Access:http://hdl.handle.net/1721.1/120104
https://orcid.org/0000-0003-4188-0414
https://orcid.org/0000-0001-6984-3004
https://orcid.org/0000-0001-9249-8181
https://orcid.org/0000-0002-0050-989X

Internet

http://hdl.handle.net/1721.1/120104
https://orcid.org/0000-0003-4188-0414
https://orcid.org/0000-0001-6984-3004
https://orcid.org/0000-0001-9249-8181
https://orcid.org/0000-0002-0050-989X

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