Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding
Ectodomain shedding of cell-surface precursor proteins by metalloproteases generates important cellular signalingmolecules. Of importance for disease is the release of ligands that activate the EGFR, such as TGFα, which is mostly carried out by ADAM17 [a member of the A-disintegrin and metalloprotea...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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American Association for Cancer Research (AACR)
2019
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| Online Access: | http://hdl.handle.net/1721.1/120104 https://orcid.org/0000-0003-4188-0414 https://orcid.org/0000-0001-6984-3004 https://orcid.org/0000-0001-9249-8181 https://orcid.org/0000-0002-0050-989X |