Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles
We sought to develop a nanoparticle vehicle that could efficiently deliver small molecule drugs to target lymphocyte populations. The synthesized amphiphilic organic ligand-protected gold nanoparticles (amph-NPs) were capable of sequestering large payloads of small molecule drugs within hydrophobic...
Main Authors: | Bekdemir, Ahmet, Watson, Nicki, Ingram, Jessica, Stellacci, Francesco R., Yang, Yu-Sang Sabrina, Moynihan, Kelly Dare, Dichwalkar, Tanmay M, Noh, Michelle M., Melo, Mariane Bandeira, Suh, Heikyung, Ploegh, Hidde, Irvine, Darrell J |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Published: |
Royal Society of Chemistry
2019
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Online Access: | http://hdl.handle.net/1721.1/120167 https://orcid.org/0000-0003-0787-298X https://orcid.org/0000-0002-1090-6071 |
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