Pushing phase and amplitude sensitivity limits in interferometric microscopy

Sensitivity of the amplitude and phasemeasurements in interferometric microscopy is influenced by factors such as instrument design and environmental interferences. Through development of a theoretical framework followed by experimental validation, we show photon shot noise is often the limiting fac...

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Bibliographic Details
Main Authors: Diaspro, Alberto, Hosseini, Poorya, Zhou, Renjie, Kim, Yang-Hyo, Peres, Chiara, Kuang, Cuifang, Yaqoob, Zahid, So, Peter T. C.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: The Optical Society 2019
Online Access:http://hdl.handle.net/1721.1/120330
https://orcid.org/0000-0001-7347-7887
https://orcid.org/0000-0002-4761-6641
https://orcid.org/0000-0001-5183-576X
https://orcid.org/0000-0003-4698-6488
Description
Summary:Sensitivity of the amplitude and phasemeasurements in interferometric microscopy is influenced by factors such as instrument design and environmental interferences. Through development of a theoretical framework followed by experimental validation, we show photon shot noise is often the limiting factor in interferometric microscopy measurements. Thereafter,wedemonstratehowa state-of-the-art camera with million-level electrons full well capacity can significantly reduce shot noise contribution resulting in a stability of optical path length down to a few picometers even in a near-common-path interferometer.