The low spike density of HIV may have evolved because of the effects of T helper cell depletion on affinity maturation
The spikes on virus surfaces bind receptors on host cells to propagate infection. High spike densities (SDs) can promote infection, but spikes are also targets of antibody-mediated immune responses. Thus, diverse evolutionary pressures can influence virus SDs. HIV's SD is about two orders of ma...
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| Format: | Article |
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Public Library of Science
2019
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| Online Access: | http://hdl.handle.net/1721.1/120486 https://orcid.org/0000-0002-8594-6529 https://orcid.org/0000-0002-1112-5912 |