Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response
Vaccination in the developing world is hampered by limited patient access, which prevents individuals from receiving the multiple injections necessary for protective immunity. Here, we developed an injectable microparticle formulation of the inactivated polio vaccine (IPV) that releases multiple pul...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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National Academy of Sciences (U.S.)
2019
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| Online Access: | http://hdl.handle.net/1721.1/120496 https://orcid.org/0000-0001-7340-0556 https://orcid.org/0000-0001-6801-4431 https://orcid.org/0000-0002-8366-3488 https://orcid.org/0000-0003-4255-0492 |
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| author | Tzeng, Stephany Y McHugh, Kevin J Behrens, Adam Rose, Sviatlana Sugarman, James L Ferber, Shiran Langer, Robert S Jaklenec, Ana |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Tzeng, Stephany Y McHugh, Kevin J Behrens, Adam Rose, Sviatlana Sugarman, James L Ferber, Shiran Langer, Robert S Jaklenec, Ana |
| author_sort | Tzeng, Stephany Y |
| collection | MIT |
| description | Vaccination in the developing world is hampered by limited patient access, which prevents individuals from receiving the multiple injections necessary for protective immunity. Here, we developed an injectable microparticle formulation of the inactivated polio vaccine (IPV) that releases multiple pulses of stable antigen over time. To accomplish this, we established an IPV stabilization strategy using cationic polymers for pH modulation to enhance traditional small-molecule–based stabilization methods. We investigated the mechanism of this strategy and showed that it was broadly applicable to all three antigens in IPV. Our lead formulations released two bursts of IPV 1 month apart, mimicking a typical vaccination schedule in the developing world. One injection of the controlled-release formulations elicited a similar or better neutralizing response in rats, considered the correlate of protection in humans, than multiple injections of liquid vaccine. This single-administration vaccine strategy has the potential to improve vaccine coverage in the developing world. Keywords: inactivated polio vaccine; vaccine stability; controlled release; global health; single-administration vaccines |
| first_indexed | 2024-09-23T08:37:48Z |
| format | Article |
| id | mit-1721.1/120496 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T08:37:48Z |
| publishDate | 2019 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/1204962022-09-23T13:26:23Z Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response Tzeng, Stephany Y McHugh, Kevin J Behrens, Adam Rose, Sviatlana Sugarman, James L Ferber, Shiran Langer, Robert S Jaklenec, Ana Koch Institute for Integrative Cancer Research at MIT Tzeng, Stephany Y McHugh, Kevin J Behrens, Adam Rose, Sviatlana Sugarman, James L Ferber, Shiran Langer, Robert S Jaklenec, Ana Vaccination in the developing world is hampered by limited patient access, which prevents individuals from receiving the multiple injections necessary for protective immunity. Here, we developed an injectable microparticle formulation of the inactivated polio vaccine (IPV) that releases multiple pulses of stable antigen over time. To accomplish this, we established an IPV stabilization strategy using cationic polymers for pH modulation to enhance traditional small-molecule–based stabilization methods. We investigated the mechanism of this strategy and showed that it was broadly applicable to all three antigens in IPV. Our lead formulations released two bursts of IPV 1 month apart, mimicking a typical vaccination schedule in the developing world. One injection of the controlled-release formulations elicited a similar or better neutralizing response in rats, considered the correlate of protection in humans, than multiple injections of liquid vaccine. This single-administration vaccine strategy has the potential to improve vaccine coverage in the developing world. Keywords: inactivated polio vaccine; vaccine stability; controlled release; global health; single-administration vaccines Bill & Melinda Gates Foundation (Grant OPP1095790) 2019-02-19T19:06:12Z 2019-02-19T19:06:12Z 2018-03 2017-12 2019-02-08T15:56:40Z Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/120496 Tzeng, Stephany Y. et al. “Stabilized Single-Injection Inactivated Polio Vaccine Elicits a Strong Neutralizing Immune Response.” Proceedings of the National Academy of Sciences 115, 23 (May 21, 2018): E5269–E5278 © 2018 National Academy of Sciences https://orcid.org/0000-0001-7340-0556 https://orcid.org/0000-0001-6801-4431 https://orcid.org/0000-0002-8366-3488 https://orcid.org/0000-0003-4255-0492 http://dx.doi.org/10.1073/PNAS.1720970115 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) PNAS |
| spellingShingle | Tzeng, Stephany Y McHugh, Kevin J Behrens, Adam Rose, Sviatlana Sugarman, James L Ferber, Shiran Langer, Robert S Jaklenec, Ana Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response |
| title | Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response |
| title_full | Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response |
| title_fullStr | Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response |
| title_full_unstemmed | Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response |
| title_short | Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response |
| title_sort | stabilized single injection inactivated polio vaccine elicits a strong neutralizing immune response |
| url | http://hdl.handle.net/1721.1/120496 https://orcid.org/0000-0001-7340-0556 https://orcid.org/0000-0001-6801-4431 https://orcid.org/0000-0002-8366-3488 https://orcid.org/0000-0003-4255-0492 |
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