A first order phase transition mechanism underlies protein aggregation in mammalian cells
The formation of misfolded protein aggregates is a hallmark of neurodegenerative diseases. The aggregate formation process exhibits an initial lag phase when precursor clusters spontaneously assemble. However, most experimental assays are blind to this lag phase. We develop a quantitative assay base...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
eLife Sciences Publications, Ltd
2019
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| Online Access: | http://hdl.handle.net/1721.1/120950 https://orcid.org/0000-0002-2269-3253 https://orcid.org/0000-0003-1867-4380 https://orcid.org/0000-0001-8493-4721 https://orcid.org/0000-0002-8764-1809 |