Coactivator condensation at super-enhancers links phase separation and gene control

Coactivator condensation at super-enhancers links phase separation and gene control

Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of the transcriptional apparatus to drive robust expression of genes with prominent roles in cell identity. Here we demonstrate that the SE-enriched transcriptional coactivators BRD4 and MED1 form nuclear punc...

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Bibliographic Details
Main Authors: Sabari, Benjamin R., Dall’Agnese, Alessandra, Boija, Ann, Klein, Isaac A., Abraham, Brian J., Hannett, Nancy M., Guo, Yang E., Day, Daniel S., Schuijers, Jurian, Hnisz, Denes, Lee, Tong Ihn, Coffey, Eliot Leo, Shrinivas, Krishna, Zamudio Montes de Oca, Alicia, Manteiga, John Colonnese, Li, Charles Han, Vasile, Eliza, Cisse, Ibrahim I, Chakraborty, Arup K, Sharp, Phillip A., Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Published: American Association for the Advancement of Science (AAAS) 2019
Online Access:http://hdl.handle.net/1721.1/120962
https://orcid.org/0000-0002-4167-9385
https://orcid.org/0000-0001-6263-2423
https://orcid.org/0000-0002-0385-6176
https://orcid.org/0000-0001-8091-6112
https://orcid.org/0000-0002-8272-658X
https://orcid.org/0000-0002-8764-1809
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0003-1268-9602
https://orcid.org/0000-0001-8855-8647

Internet

http://hdl.handle.net/1721.1/120962
https://orcid.org/0000-0002-4167-9385
https://orcid.org/0000-0001-6263-2423
https://orcid.org/0000-0002-0385-6176
https://orcid.org/0000-0001-8091-6112
https://orcid.org/0000-0002-8272-658X
https://orcid.org/0000-0002-8764-1809
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0003-1268-9602
https://orcid.org/0000-0001-8855-8647

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