Coactivator condensation at super-enhancers links phase separation and gene control
Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of the transcriptional apparatus to drive robust expression of genes with prominent roles in cell identity. Here we demonstrate that the SE-enriched transcriptional coactivators BRD4 and MED1 form nuclear punc...
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| Format: | Article |
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American Association for the Advancement of Science (AAAS)
2019
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| Online Access: | http://hdl.handle.net/1721.1/120962 https://orcid.org/0000-0002-4167-9385 https://orcid.org/0000-0001-6263-2423 https://orcid.org/0000-0002-0385-6176 https://orcid.org/0000-0001-8091-6112 https://orcid.org/0000-0002-8272-658X https://orcid.org/0000-0002-8764-1809 https://orcid.org/0000-0003-1465-1691 https://orcid.org/0000-0003-1268-9602 https://orcid.org/0000-0001-8855-8647 |