Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression

Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression

Down syndrome (DS, trisomy 21) is associated with developmental abnormalities and increased leukemia risk. To reconcile chromatin alterations with transcriptome changes, we performed paired exogenous spike-in normalized RNA and chromatin immunoprecipitation sequencing in DS models. Absolute normaliz...

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Bibliographic Details
Main Authors: Mowery, Cody T., Reyes, Jaime M., Cabal-Hierro, Lucia, Higby, Kelly J., Karlin, Kristen L., Wang, Jarey H., Cejas, Paloma, Lim, Klothilda, Li, Hubo, Furusawa, Takashi, Long, Henry W., Pellman, David, Chapuy, Bjoern, Bustin, Michael, Westbrook, Thomas F., Lin, Charles Y., Lane, Andrew A., Kimmerling, Robert John, Manalis, Scott R
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Elsevier 2019
Online Access:http://hdl.handle.net/1721.1/120994
https://orcid.org/0000-0001-9939-764X
https://orcid.org/0000-0001-5223-9433

Internet

http://hdl.handle.net/1721.1/120994
https://orcid.org/0000-0001-9939-764X
https://orcid.org/0000-0001-5223-9433

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