Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

Triple-negative breast cancers (TNBC) are genetically characterized by aberrations in TP53 and a low rate of activating point mutations in common oncogenes, rendering it challenging in applying targeted therapies. We performed whole-exome sequencing (WES) and RNA sequencing (RNA-seq) to identify som...

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Bibliographic Details
Main Authors: Murphy, Charles J., Karreth, Florian A., Elemento, Olivier, Toker, Alex, Wulf, Gerburg M., Cantley, Lewis C., Yang, Kangkang, Liu, Hui, Emdal, Kristina Bennet, Cantley, Lewis C, White, Forest M.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: American Association for Cancer Research (AACR) 2019
Online Access:http://hdl.handle.net/1721.1/121024
https://orcid.org/0000-0001-6483-9110
https://orcid.org/0000-0002-1545-1651

Internet

http://hdl.handle.net/1721.1/121024
https://orcid.org/0000-0001-6483-9110
https://orcid.org/0000-0002-1545-1651

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