Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer
Triple-negative breast cancers (TNBC) are genetically characterized by aberrations in TP53 and a low rate of activating point mutations in common oncogenes, rendering it challenging in applying targeted therapies. We performed whole-exome sequencing (WES) and RNA sequencing (RNA-seq) to identify som...
Main Authors: | Murphy, Charles J., Karreth, Florian A., Elemento, Olivier, Toker, Alex, Wulf, Gerburg M., Cantley, Lewis C., Yang, Kangkang, Liu, Hui, Emdal, Kristina Bennet, Cantley, Lewis C, White, Forest M. |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Published: |
American Association for Cancer Research (AACR)
2019
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Online Access: | http://hdl.handle.net/1721.1/121024 https://orcid.org/0000-0001-6483-9110 https://orcid.org/0000-0002-1545-1651 |
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