A quasi-integral controller for adaptation of genetic modules to variable ribosome demand
The behavior of genetic circuits is often poorly predictable. A gene’s expression level is not only determined by the intended regulators, but also affected by changes in ribosome availability imparted by expression of other genes. Here we design a quasi-integral biomolecular feedback controller tha...
Main Authors: | Huang, Hsin-Ho, Qian, Yili, Del Vecchio, Domitilla |
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Other Authors: | Massachusetts Institute of Technology. Department of Mechanical Engineering |
Format: | Article |
Published: |
Nature Publishing Group
2019
|
Online Access: | http://hdl.handle.net/1721.1/121039 https://orcid.org/0000-0003-2435-480X https://orcid.org/0000-0002-1097-0401 https://orcid.org/0000-0001-6472-8576 |
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