EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

Many cancer types are driven by oncogenic transcription factors that have been difficult to drug. Transcriptional inhibitors, however, may offer inroads into targeting these cancers. Through chemical genomics screening, we identified that Ewing sarcoma is a disease with preferential sensitivity to T...

Полное описание

Библиографические подробности
Главные авторы: Iniguez, Amanda Balboni, Stolte, Björn, Wang, Emily Jue, Conway, Amy Saur, Alexe, Gabriela, Dharia, Neekesh V., Kwiatkowski, Nicholas, Zhang, Tinghu, Abraham, Brian J., Mora, Jaume, Kalev, Peter, Leggett, Alan, Chowdhury, Dipanjan, Benes, Cyril H., Gray, Nathanael S., Stegmaier, Kimberly, Young, Richard A.
Другие авторы: Massachusetts Institute of Technology. Department of Biology
Формат: Статья
Опубликовано: Elsevier BV 2019
Online-ссылка:http://hdl.handle.net/1721.1/121107
https://orcid.org/0000-0001-8855-8647

Internet

http://hdl.handle.net/1721.1/121107
https://orcid.org/0000-0001-8855-8647

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