Dynamic control of endogenous metabolism with combinatorial logic circuits

Controlling gene expression during a bioprocess enables real-time metabolic control, coordinated cellular responses, and staging order-of-operations. Achieving this with small molecule inducers is impractical at scale and dynamic circuits are difficult to design. Here, we show that the same set of s...

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Bibliographic Details
Main Authors: Moser, Felix, Espah Borujeni, Amin, Ghodasara, Amar Navin, Cameron, Douglas, Park, YongJin, Voigt, Christopher A.
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Published: Nature Publishing Group 2019
Online Access:http://hdl.handle.net/1721.1/121120
https://orcid.org/0000-0002-7762-3084
https://orcid.org/0000-0002-3036-7183
https://orcid.org/0000-0001-5409-1831
https://orcid.org/0000-0002-6788-2429
https://orcid.org/0000-0003-0844-4776