Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci

Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci

To assess the impact of genetic variation in regulatory loci on human health, we constructed a high-resolution map of allelic imbalances in DNA methylation, histone marks, and gene transcription in 71 epigenomes from 36 distinct cell and tissue types from 13 donors. Deep whole-genome bisulfite seque...

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Bibliographic Details
Main Authors: Altshuler, Robert Charles, Onuchic, Vitor, Lurie, Eugene, Carrero, Ivenise, Pawliczek, Piotr, Patel, Ronak Y., Rozowsky, Joel, Galeev, Timur, Huang, Zhuoyi, Harris, R. Alan, Coarfa, Cristian, Ashmore, Lillian, Bertol, Jessica W., Fakhouri, Walid D., Yu, Fuli, Kellis, Manolis, Gerstein, Mark, Milosavljevic, Aleksandar
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2019
Online Access:https://hdl.handle.net/1721.1/121218

Internet

https://hdl.handle.net/1721.1/121218

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