Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to ∼370,000 women, we identify 389 independent signals (P < 5 × 10⁻⁸) for age at menarche, a milestone in female pub...

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Bibliographic Details
Main Authors: Finucane, Hilary Kiyo, Sarkar, Abhishek Kulshreshtha
Other Authors: Massachusetts Institute of Technology. Department of Mathematics
Format: Article
Language:English
Published: Nature Publishing Group 2019
Online Access:https://hdl.handle.net/1721.1/121221