Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to ∼370,000 women, we identify 389 independent signals (P < 5 × 10⁻⁸) for age at menarche, a milestone in female pub...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019
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| Online Access: | https://hdl.handle.net/1721.1/121221 |