Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age

Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age

Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal's lifespan. However, with age, the balance is disrupted, and LT-HSCs produce a myeloid-biased output, resulting in poor immune responses to infectious challenge and the development of myeloid leukemi...

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Bibliographic Details
Main Authors: Mann, Mati, Mehta, Arnav, de Boer, Carl G., Kowalczyk, Monika S., Lee, Kevin, Haldeman, Pearce, Rogel, Noga, Knecht, Abigail R., Farouq, Daneyal, Regev, Aviv, Baltimore, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier 2019
Online Access:https://hdl.handle.net/1721.1/121253

Internet

https://hdl.handle.net/1721.1/121253

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