RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

Removal of damaged mitochondria is orchestrated by a pathway involving the PINK1 kinase and the PARKIN ubiquitin ligase. Ubiquitin chains assembled by PARKIN on the mitochondrial outer membrane recruit autophagy cargo receptors in complexes with TBK1 protein kinase. While TBK1 is known to phosphoryl...

詳細記述

書誌詳細
主要な著者: Heo, J.-M., Ordureau, A., Swarup, S., Paulo, J. A., Shen, K., Sabatini, David, Harper, J. W.
その他の著者: Massachusetts Institute of Technology. Department of Biology
フォーマット: 論文
出版事項: American Association for the Advancement of Science (AAAS) 2019
オンライン・アクセス:https://hdl.handle.net/1721.1/121350