Stochasticity is necessary for multiple attractors in a class of differentiation networks

Deterministic models remain the most common option for modeling gene regulatory networks even when the underlying assumptions of high copy numbers and fast promoter kinetics are unsatisfied. Here, we analyze a widely studied differentiation network motif known as the PU.1-GATA-1 circuit and we show...

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Bibliographic Details
Main Authors: Kumar, Nithin Senthur, Al-Radhawi, Muhammad Ali, Sontag, Eduardo D., Del Vecchio, Domitilla
Other Authors: Massachusetts Institute of Technology. Department of Mechanical Engineering
Format: Article
Language:en_US
Published: Institute of Electrical and Electronics Engineers (IEEE) 2019
Online Access:https://hdl.handle.net/1721.1/121528