MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling

MicroRNAs (miRs) contribute to biological robustness by buffering cellular processes from external perturbations. Here we report an unexpected link between DNA damage response and angiogenic signaling that is buffered by a miR. We demonstrate that genotoxic stress-induced miR-494 inhibits the DNA re...

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Bibliographic Details
Main Authors: Espinosa-Diez, Cristina, Wilson, RaeAnna, Chatterjee, Namita, Hudson, Clayton, Ruhl, Rebecca, Hipfinger, Christina, Helms, Erin, Khan, Omar Fizal, Anderson, Daniel Griffith, Anand, Sudarshan
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2019
Online Access:https://hdl.handle.net/1721.1/121975

Internet

https://hdl.handle.net/1721.1/121975

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