Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers

Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers

Cyclins and cyclin-dependent kinases (CDKs) are hyperactivated in numerous human tumors. To identify means of interfering with cyclins/CDKs, we performed nine genome-wide screens for human microRNAs (miRNAs) directly regulating cell-cycle proteins. We uncovered a distinct class of miRNAs that target...

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Bibliographic Details
Main Authors: Hydbring, Per, Wang, Yinan, Fassl, Anne, Li, Xiaoting, Matia, Veronica, Otto, Tobias, Choi, Yoon Jong, Sweeney, Katharine E., Suski, Jan M., Yin, Hao, Bogorad, Roman, Goel, Shom, Yuzugullu, Haluk, Kauffman, Kevin John, Yang, Jung H, Jin, Chong, Li, Yingxiang, Floris, Davide, Swanson, Richard, Ng, Kimmie, Sicinska, Ewa, Anders, Lars, Zhao, Jean J., Polyak, Kornelia, Anderson, Daniel Griffith, Li, Cheng, Sicinski, Piotr
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: Elsevier BV 2019
Online Access:https://hdl.handle.net/1721.1/121983

Internet

https://hdl.handle.net/1721.1/121983

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