Identification of cell cycle-targeting microRNAs through genome-wide screens
By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects wit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Informa UK Limited
2019
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| Online Access: | https://hdl.handle.net/1721.1/121999 |
| _version_ | 1826210176445710336 |
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| author | Bogorad, Roman Yin, Hao Anderson, Daniel Griffith |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Bogorad, Roman Yin, Hao Anderson, Daniel Griffith |
| author_sort | Bogorad, Roman |
| collection | MIT |
| description | By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects without affecting animals' health. Here, we provide an in-depth description of our miRNA screening methodology, analyses of selected cell cycle-targeting miRNAs, and discuss why miRNA therapy might be a viable therapeutic option for cancer patients. |
| first_indexed | 2024-09-23T14:45:06Z |
| format | Article |
| id | mit-1721.1/121999 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:45:06Z |
| publishDate | 2019 |
| publisher | Informa UK Limited |
| record_format | dspace |
| spelling | mit-1721.1/1219992022-09-29T10:20:15Z Identification of cell cycle-targeting microRNAs through genome-wide screens Bogorad, Roman Yin, Hao Anderson, Daniel Griffith Harvard University--MIT Division of Health Sciences and Technology Koch Institute for Integrative Cancer Research at MIT Developmental Biology Cell Biology Molecular Biology By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects without affecting animals' health. Here, we provide an in-depth description of our miRNA screening methodology, analyses of selected cell cycle-targeting miRNAs, and discuss why miRNA therapy might be a viable therapeutic option for cancer patients. 2019-08-19T13:14:26Z 2019-08-19T13:14:26Z 2017-11-14 2019-08-09T13:22:07Z Article http://purl.org/eprint/type/JournalArticle 1538-4101 1551-4005 https://hdl.handle.net/1721.1/121999 Hydbringa, Per, Yinan Wang, Roman L. Bogorad, Hao Yin, Daniel G. Andersond, Cheng Li, and Piotr Sicinski. "Identification of cell cycle-targeting microRNAs through genome-wide screens." Cell cycle, 16, no. 23 (Nov. 2017): pp. 2241-2248. © 2017 The Author(s) en 10.1080/15384101.2017.1380132 Cell cycle Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Informa UK Limited Taylor & Francis |
| spellingShingle | Developmental Biology Cell Biology Molecular Biology Bogorad, Roman Yin, Hao Anderson, Daniel Griffith Identification of cell cycle-targeting microRNAs through genome-wide screens |
| title | Identification of cell cycle-targeting microRNAs through genome-wide screens |
| title_full | Identification of cell cycle-targeting microRNAs through genome-wide screens |
| title_fullStr | Identification of cell cycle-targeting microRNAs through genome-wide screens |
| title_full_unstemmed | Identification of cell cycle-targeting microRNAs through genome-wide screens |
| title_short | Identification of cell cycle-targeting microRNAs through genome-wide screens |
| title_sort | identification of cell cycle targeting micrornas through genome wide screens |
| topic | Developmental Biology Cell Biology Molecular Biology |
| url | https://hdl.handle.net/1721.1/121999 |
| work_keys_str_mv | AT bogoradroman identificationofcellcycletargetingmicrornasthroughgenomewidescreens AT yinhao identificationofcellcycletargetingmicrornasthroughgenomewidescreens AT andersondanielgriffith identificationofcellcycletargetingmicrornasthroughgenomewidescreens |