Total Synthesis and Anti-Cancer Activity of All Known Communesin Alkaloids and Related Derivatives

A unified enantioselective total synthesis and anticancer evaluation of all known epoxide-containing communesin alkaloids and related derivatives is described. Our synthesis is predicated on the convergent and modular diazene-directed assembly of two complex fragments to secure the critical C3a-C3a&...

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Bibliographic Details
Main Authors: Pompeo, Matthew M, Cheah, Jaime H, Movassaghi, Mohammad
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: American Chemical Society (ACS) 2019
Online Access:https://hdl.handle.net/1721.1/122288