Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity

Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity

Despite studies indicating the effects of IL-21 signaling in intestinal inflammation, its roles in intestinal homeostasis and infection are not yet clear. Here, we report potent effects of commensal microbiota on the phenotypic manifestations of IL-21 receptor deficiency. IL-21 is produced highly in...

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Bibliographic Details
Main Authors: Cho, Hyeseon, Jaime, Henrique, de Oliveira, Rafael Pires, Kang, Byunghyun, Spolski, Rosanne, Vaziri, Tina, Myers, Timothy G., Thovarai, Vishal, Shen, Zeli, Fox, James G., Leonard, Warren J., Kelsall, Brian L.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Springer Science and Business Media 2019
Online Access:https://hdl.handle.net/1721.1/122642

Internet

https://hdl.handle.net/1721.1/122642

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