Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity
Despite studies indicating the effects of IL-21 signaling in intestinal inflammation, its roles in intestinal homeostasis and infection are not yet clear. Here, we report potent effects of commensal microbiota on the phenotypic manifestations of IL-21 receptor deficiency. IL-21 is produced highly in...
| Main Authors: | , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer Science and Business Media
2019
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| Online Access: | https://hdl.handle.net/1721.1/122642 |
| _version_ | 1811078552787877888 |
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| author | Cho, Hyeseon Jaime, Henrique de Oliveira, Rafael Pires Kang, Byunghyun Spolski, Rosanne Vaziri, Tina Myers, Timothy G. Thovarai, Vishal Shen, Zeli Fox, James G. Leonard, Warren J. Kelsall, Brian L. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Cho, Hyeseon Jaime, Henrique de Oliveira, Rafael Pires Kang, Byunghyun Spolski, Rosanne Vaziri, Tina Myers, Timothy G. Thovarai, Vishal Shen, Zeli Fox, James G. Leonard, Warren J. Kelsall, Brian L. |
| author_sort | Cho, Hyeseon |
| collection | MIT |
| description | Despite studies indicating the effects of IL-21 signaling in intestinal inflammation, its roles in intestinal homeostasis and infection are not yet clear. Here, we report potent effects of commensal microbiota on the phenotypic manifestations of IL-21 receptor deficiency. IL-21 is produced highly in the small intestine and appears to be critical for mounting an IgA response against atypical commensals such as segmented filamentous bacteria and Helicobacter, but not to the majority of commensals. In the presence of these atypical commensals, IL-21R-deficient mice exhibit reduced numbers of germinal center and IgA⁺ B cells and expression of activation-induced cytidine deaminase in Peyer’s patches as well as a significant decrease in small intestine IgA⁺ plasmablasts and plasma cells, leading to higher bacterial burdens and subsequent expansion of Th17 and Treg cells. These microbiota-mediated secondary changes in turn enhance T cell responses to an oral antigen and strikingly dampen Citrobacter rodentium-induced immunopathology, demonstrating a complex interplay between IL-21-mediated mucosal immunity, microbiota, and pathogens. |
| first_indexed | 2024-09-23T11:02:00Z |
| format | Article |
| id | mit-1721.1/122642 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:02:00Z |
| publishDate | 2019 |
| publisher | Springer Science and Business Media |
| record_format | dspace |
| spelling | mit-1721.1/1226422022-10-01T00:41:09Z Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity Cho, Hyeseon Jaime, Henrique de Oliveira, Rafael Pires Kang, Byunghyun Spolski, Rosanne Vaziri, Tina Myers, Timothy G. Thovarai, Vishal Shen, Zeli Fox, James G. Leonard, Warren J. Kelsall, Brian L. Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Division of Comparative Medicine Despite studies indicating the effects of IL-21 signaling in intestinal inflammation, its roles in intestinal homeostasis and infection are not yet clear. Here, we report potent effects of commensal microbiota on the phenotypic manifestations of IL-21 receptor deficiency. IL-21 is produced highly in the small intestine and appears to be critical for mounting an IgA response against atypical commensals such as segmented filamentous bacteria and Helicobacter, but not to the majority of commensals. In the presence of these atypical commensals, IL-21R-deficient mice exhibit reduced numbers of germinal center and IgA⁺ B cells and expression of activation-induced cytidine deaminase in Peyer’s patches as well as a significant decrease in small intestine IgA⁺ plasmablasts and plasma cells, leading to higher bacterial burdens and subsequent expansion of Th17 and Treg cells. These microbiota-mediated secondary changes in turn enhance T cell responses to an oral antigen and strikingly dampen Citrobacter rodentium-induced immunopathology, demonstrating a complex interplay between IL-21-mediated mucosal immunity, microbiota, and pathogens. 2019-10-21T15:13:11Z 2019-10-21T15:13:11Z 2018-08 2018-05 2019-10-17T13:25:53Z Article http://purl.org/eprint/type/JournalArticle 1933-0219 1935-3456 https://hdl.handle.net/1721.1/122642 Cho, Hyeseon et al. "Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity." Mucosal Immunology 12 (August 2018): 85–96 © 2018 The Author(s) en http://dx.doi.org/10.1038/s41385-018-0056-x Mucosal Immunology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Science and Business Media Nature |
| spellingShingle | Cho, Hyeseon Jaime, Henrique de Oliveira, Rafael Pires Kang, Byunghyun Spolski, Rosanne Vaziri, Tina Myers, Timothy G. Thovarai, Vishal Shen, Zeli Fox, James G. Leonard, Warren J. Kelsall, Brian L. Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity |
| title | Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity |
| title_full | Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity |
| title_fullStr | Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity |
| title_full_unstemmed | Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity |
| title_short | Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity |
| title_sort | defective iga response to atypical intestinal commensals in il 21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity |
| url | https://hdl.handle.net/1721.1/122642 |
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