Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity
Despite studies indicating the effects of IL-21 signaling in intestinal inflammation, its roles in intestinal homeostasis and infection are not yet clear. Here, we report potent effects of commensal microbiota on the phenotypic manifestations of IL-21 receptor deficiency. IL-21 is produced highly in...
Main Authors: | Cho, Hyeseon, Jaime, Henrique, de Oliveira, Rafael Pires, Kang, Byunghyun, Spolski, Rosanne, Vaziri, Tina, Myers, Timothy G., Thovarai, Vishal, Shen, Zeli, Fox, James G., Leonard, Warren J., Kelsall, Brian L. |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media
2019
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Online Access: | https://hdl.handle.net/1721.1/122642 |
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