Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa

Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa

Pseudomonas aeruginosa is a major bacterial pathogen associated with a rising prevalence of antibiotic resistance. We evaluated the resistance mechanisms of P. aeruginosa against POL7080, a species-specific, first-in-class antibiotic in clinical trials that targets the lipopolysaccharide transport p...

Full description

Bibliographic Details
Main Authors: Romano, Keith P., Warrier, Thulasi, Poulsen, Bradley E., Nguyen, Phuong H., Loftis, Alexander R., Saebi, Azin, Pentelute, Bradley L., Hung, Deborah T
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: American Society for Microbiology 2020
Online Access:https://hdl.handle.net/1721.1/123439

Internet

https://hdl.handle.net/1721.1/123439

Similar Items