Phenotype of ribonuclease 1 deficiency in mice

Biological roles for extracellular RNA (eRNA) have become apparent. For example, eRNA can induce contact activation in blood via activation of the plasma proteases factor XII (FXII) and factor XI (FXI). We sought to reveal the biological role of the secretory enzyme ribonuclease 1 (RNase 1) in an or...

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Bibliographic Details
Main Authors: Garnett, Emily Rose, Lomax, Jo E., Mohammed, Bassem M., Gailani, David, Sheehan, John P., Raines, Ronald T
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory 2020
Online Access:https://hdl.handle.net/1721.1/123444