Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids

Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids

Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here, we identify a set of synthetic glycosphingolipids that harness the endogenous process of intracellular lipid-sorting to enable mucosal absor...

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Bibliographic Details
Main Authors: Garcia-Castillo, Maria Daniela, Chinnapen, Daniel J F, te Welscher, Yvonne M, Gonzalez, Rodrigo J, Softic, Samir, Pacheco, Michele, Mrsny, Randall J, Kahn, C Ronald, von Andrian, Ulrich H, Lau, Jesper, Pentelute, Bradley L., Lencer, Wayne I
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd. 2020
Subjects:
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Neuroscience
General Medicine
Online Access:https://hdl.handle.net/1721.1/123515

Internet

https://hdl.handle.net/1721.1/123515

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