Site-Selective Cysteine-Cyclooctyne Conjugation

Site-Selective Cysteine-Cyclooctyne Conjugation

We report a site-selective cysteine–cyclooctyne conjugation reaction between a seven-residue peptide tag (DBCO-tag, Leu-Cys-Tyr-Pro-Trp-Val-Tyr) at the N or C terminus of a peptide or protein and various aza-dibenzocyclooctyne (DBCO) reagents. Compared to a cysteine peptide control, the DBCO-tag inc...

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Bibliographic Details
Main Authors: Zhang, Chi, Dai, Peng, Vinogradov, Alexander A., Gates, Zachary P, Pentelute, Bradley L.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Wiley 2020
Online Access:https://hdl.handle.net/1721.1/123516

Internet

https://hdl.handle.net/1721.1/123516

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