Perfluoroaryl Bicyclic Cell-Penetrating Peptides for Delivery of Antisense Oligonucleotides

Perfluoroaryl Bicyclic Cell-Penetrating Peptides for Delivery of Antisense Oligonucleotides

Exon-skipping antisense oligonucleotides are effective treatments for genetic diseases, yet exon-skipping activity requires that these macromolecules reach the nucleus. While cell-penetrating peptides can improve delivery, proteolytic instability often limits efficacy. It is hypothesized that the bi...

Full description

Bibliographic Details
Main Authors: Wolfe, Justin, Fadzen, Colin M., Holden, Rebecca Lynn, Yao, Monica, Hanson, Gunnar J., Pentelute, Bradley L.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Wiley 2020
Subjects:
General Chemistry
Catalysis
Online Access:https://hdl.handle.net/1721.1/123522

Internet

https://hdl.handle.net/1721.1/123522

Similar Items