Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin–Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity
Enteric Gram-negative bacteria, including Escherichia coli, biosynthesize and deploy the triscatecholate siderophore enterobactin (Ent) in the vertebrate host to acquire iron, an essential nutrient. We report that Ent-Cipro, a synthetic siderophore-antibiotic conjugate based on the native Ent platfo...
| Hoofdauteurs: | , , , |
|---|---|
| Andere auteurs: | |
| Formaat: | Artikel |
| Taal: | English |
| Gepubliceerd in: |
American Chemical Society (ACS)
2020
|
| Online toegang: | https://hdl.handle.net/1721.1/123660 |