A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins

A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins

Conjugates between proteins and small molecules enable access to a vast chemical space that is not achievable with either type of molecule alone; however, the paucity of specific reactions capable of functionalizing proteins and natural products presents a formidable challenge for preparing conjugat...

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Bibliographic Details
Main Authors: Cohen, Daniel Tzvi, Zhang, Chi, Fadzen, Colin M., Mijalis, Alexander James, Hie, Liana, Johnson, Kenneth D., Shriver, Zachary, Plante, Obadiah, Miller, Scott J., Buchwald, Stephen Leffler, Pentelute, Bradley L.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Online Access:https://hdl.handle.net/1721.1/123668

Internet

https://hdl.handle.net/1721.1/123668

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