Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics

Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics

In vitro models of the blood–brain barrier (BBB) are critical tools for the study of BBB transport and the development of drugs that can reach the CNS. Brain endothelial cells grown in culture are often used to model the BBB; however, it is challenging to maintain reproducible BBB properties and fun...

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Bibliographic Details
Main Authors: Bergmann, Sonja, Lawler, Sean E., Qu, Yuan, Fadzen, Colin M., Wolfe, Justin, Regan, Michael S., Pentelute, Bradley L., Agar, Nathalie Y. R., Cho, Choi-Fong
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Springer Nature 2020
Online Access:https://hdl.handle.net/1721.1/123679

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https://hdl.handle.net/1721.1/123679

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