Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex1–4. The large subunit of Pol II contains an intrinsically disordered C-terminal domain that is phosphorylated by cyclin-dependent kinases du...

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Bibliographic Details
Main Authors: Manteiga, John Colonnese, Spille, Jan Hendrik, Afeyan, Lena K., Zamudio Montes de Oca, Alicia, Shrinivas, Krishna, Cisse, Ibrahim I, Sharp, Phillip A., Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Subjects:
Multidisciplinary
Online Access:https://hdl.handle.net/1721.1/124351

Internet

https://hdl.handle.net/1721.1/124351

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