Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex1–4. The large subunit of Pol II contains an intrinsically disordered C-terminal domain that is phosphorylated by cyclin-dependent kinases du...

书目详细资料
Main Authors:	Manteiga, John Colonnese, Spille, Jan Hendrik, Afeyan, Lena K., Zamudio Montes de Oca, Alicia, Shrinivas, Krishna, Cisse, Ibrahim I, Sharp, Phillip A., Young, Richard A.
其他作者:	Massachusetts Institute of Technology. Department of Biology
格式:	文件
语言:	English
出版:	Springer Science and Business Media LLC 2020
主题:	Multidisciplinary
在线阅读:	https://hdl.handle.net/1721.1/124351

相似书籍

Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes
由: Zamudio Montes de Oca, Alicia, et al.
出版: (2021)

CDK12 regulates DNA repair genes by suppressing intronic polyadenylation
由: Dubbury, Sara J., et al.
出版: (2020)

Coactivator condensation at super-enhancers links phase separation and gene control
由: Sabari, Benjamin R., et al.
出版: (2019)

Insights from biomolecular condensates into disease and drug development
由: Afeyan, Lena K.
出版: (2022)

RNA-Mediated Feedback Control of Transcriptional Condensates
由: Henninger, Jonathan E, et al.
出版: (2022)

Enhancer Features that Drive Formation of Transcriptional Condensates
由: Shrinivas, Krishna, et al.
出版: (2021)

Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism
由: Schuijers, Jurian, et al.
出版: (2018)

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
由: Cho, Won-ki, et al.
出版: (2020)

Scientific machine learning for modeling and simulating complex fluids
由: Lennon, Kyle R., et al.
出版: (2024)

Achieving high-temperature ferromagnetic topological insulating phase by proximity coupling
由: Katmis, Ferhat, et al.
出版: (2023)

Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program
由: Kang, Seong Anthony Woo, et al.
出版: (2020)

Predictions of novel Schistosoma mansoni-human protein interactions consistent with experimental data
由: White Bear, Javona, et al.
出版: (2020)

Comprehensive comparison of pore-scale models for multiphase flow in porous media
由: Primkulov, Bauyrzhan K.
出版: (2020)

Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications
由: Almeqdadi, Mohammad, et al.
出版: (2020)

Characteristic disruptions of an excitable carbon cycle
由: Rothman, Daniel H.
出版: (2020)

Deep elastic strain engineering of bandgap through machine learning
由: Shi, Zhe, et al.
出版: (2020)

Biohybrid valveless pump-bot powered by engineered skeletal muscle
由: Kamm, Roger D.
出版: (2020)

Atomic structure of the open SARS-CoV-2 E viroporin
由: Medeiros-Silva, João, et al.
出版: (2024)

Will microfluidics enable functionally integrated biohybrid robots?
由: Filippi, Miriam, et al.
出版: (2024)

Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade
由: Weinberg, Robert A. (Robert Allan), 1942-
出版: (2020)

OrgaQuant: Human Intestinal Organoid Localization and Quantification Using Deep Convolutional Neural Networks
由: Kassis, Timothy, et al.
出版: (2020)

Universal amplification-free molecular diagnostics by billion-fold hierarchical nanofluidic concentration
由: Ouyang, Wei, et al.
出版: (2020)

Quantifying stochastic uncertainty in detection time of human-caused climate signals
由: Solomon, Susan
出版: (2020)

Regularizations of time-crystal dynamics
由: Wilczek, Frank
出版: (2020)

High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments
由: Hu, Jiliang, et al.
出版: (2020)

CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer
由: Ng, Sheng Rong, et al.
出版: (2020)

In vitro evolution of enhanced RNA replicons for immunotherapy
由: Li, Yingzhong, et al.
出版: (2020)

Travel distance, frequency of return, and the spread of disease
由: Heine, Cate, et al.
出版: (2024)

Whose data can we trust: How meta-predictions can be used to uncover credible respondents in survey data
由: Radas, Sonja, et al.
出版: (2022)

Biosynthesis of the nitrogenase active-site cofactor precursor NifB-co in Saccharomyces cerevisiae
由: Saaem, Ishtiaq Ali, et al.
出版: (2020)

Selective sulfidation of metal compounds
由: Stinn, Caspar, et al.
出版: (2024)

Affective mirror and anti-mirror neurons relate to prosocial help in rats
由: Wu, Wen-Yi, et al.
出版: (2023)

Gene-guided discovery and engineering of branched cyclic peptides in plants
由: Kersten, Roland D., et al.
出版: (2020)

Expanding the stoichiometric window for metal cross-linked gel assembly using competition
由: Cazzell, Seth Allen, et al.
出版: (2020)

An ingestible self-orienting system for oral delivery of macromolecules
由: Abramson, Alex, et al.
出版: (2020)

The evolution of red color vision is linked to coordinated rhodopsin tuning in lycaenid butterflies
由: Liénard, Marjorie A., et al.
出版: (2022)

A relatively wide-bandgap and air-stable donor polymer for fabrication of efficient semitransparent and tandem organic photovoltaics
由: Tavakoli, Mohammad Mahdi, et al.
出版: (2020)

Generalized neural closure models with interpretability
由: Gupta, Abhinav, et al.
出版: (2024)

Predicting neighborhoods’ socioeconomic attributes using restaurant data
由: Dong, Lei, et al.
出版: (2020)

Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells
由: Zhang, Bing, et al.
出版: (2020)