An ingestible self-orienting system for oral delivery of macromolecules
Biomacromolecules have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit their administration to parenteral routes. An oral biologic delivery system must aid in both localization and permeat...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2020
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| Online Access: | https://hdl.handle.net/1721.1/124359 |
| _version_ | 1826215461981782016 |
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| author | Abramson, Alex Caffarel Salvador, Ester Khang, Minsoo Dellal, David Silverstein, David Gao, Yuan Cleveland, Cody Collins, Joy E Tamang, Siddartha M Hayward, Alison M Roxhed, Niclas Langer, Robert S Traverso, Carlo Giovanni |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Abramson, Alex Caffarel Salvador, Ester Khang, Minsoo Dellal, David Silverstein, David Gao, Yuan Cleveland, Cody Collins, Joy E Tamang, Siddartha M Hayward, Alison M Roxhed, Niclas Langer, Robert S Traverso, Carlo Giovanni |
| author_sort | Abramson, Alex |
| collection | MIT |
| description | Biomacromolecules have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit their administration to parenteral routes. An oral biologic delivery system must aid in both localization and permeation to achieve systemic drug uptake. Inspired by the leopard tortoise’s ability to passively reorient, we developed an ingestible self-orienting millimeter-scale applicator (SOMA) that autonomously positions itself to engage with GI tissue. It then deploys milliposts fabricated from active pharmaceutical ingredients directly through the gastric mucosa while avoiding perforation. We conducted in vivo studies in rats and swine that support the applicator’s safety and, using insulin as a model drug, demonstrated that the SOMA delivers active pharmaceutical ingredient plasma levels comparable to those achieved with subcutaneous millipost administration. |
| first_indexed | 2024-09-23T16:30:09Z |
| format | Article |
| id | mit-1721.1/124359 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:30:09Z |
| publishDate | 2020 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1243592022-09-29T20:01:43Z An ingestible self-orienting system for oral delivery of macromolecules Abramson, Alex Caffarel Salvador, Ester Khang, Minsoo Dellal, David Silverstein, David Gao, Yuan Cleveland, Cody Collins, Joy E Tamang, Siddartha M Hayward, Alison M Roxhed, Niclas Langer, Robert S Traverso, Carlo Giovanni Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Division of Comparative Medicine Massachusetts Institute of Technology. Media Laboratory Massachusetts Institute of Technology. Department of Mechanical Engineering Massachusetts Institute of Technology. Department of Biological Engineering Koch Institute for Integrative Cancer Research at MIT Multidisciplinary Biomacromolecules have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit their administration to parenteral routes. An oral biologic delivery system must aid in both localization and permeation to achieve systemic drug uptake. Inspired by the leopard tortoise’s ability to passively reorient, we developed an ingestible self-orienting millimeter-scale applicator (SOMA) that autonomously positions itself to engage with GI tissue. It then deploys milliposts fabricated from active pharmaceutical ingredients directly through the gastric mucosa while avoiding perforation. We conducted in vivo studies in rats and swine that support the applicator’s safety and, using insulin as a model drug, demonstrated that the SOMA delivers active pharmaceutical ingredient plasma levels comparable to those achieved with subcutaneous millipost administration. National Institutes of Health (U.S.) (grant EB-000244) 2020-03-26T15:15:40Z 2020-03-26T15:15:40Z 2019-02-07 2020-02-19T19:12:05Z Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 https://hdl.handle.net/1721.1/124359 Abramson, Alex et al. "An ingestible self-orienting system for oral delivery of macromolecules." Science 363 (2019): 611-615 © 2019 The Author(s) en 10.1126/science.aau2277 Science Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) PMC |
| spellingShingle | Multidisciplinary Abramson, Alex Caffarel Salvador, Ester Khang, Minsoo Dellal, David Silverstein, David Gao, Yuan Cleveland, Cody Collins, Joy E Tamang, Siddartha M Hayward, Alison M Roxhed, Niclas Langer, Robert S Traverso, Carlo Giovanni An ingestible self-orienting system for oral delivery of macromolecules |
| title | An ingestible self-orienting system for oral delivery of macromolecules |
| title_full | An ingestible self-orienting system for oral delivery of macromolecules |
| title_fullStr | An ingestible self-orienting system for oral delivery of macromolecules |
| title_full_unstemmed | An ingestible self-orienting system for oral delivery of macromolecules |
| title_short | An ingestible self-orienting system for oral delivery of macromolecules |
| title_sort | ingestible self orienting system for oral delivery of macromolecules |
| topic | Multidisciplinary |
| url | https://hdl.handle.net/1721.1/124359 |
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