Gain-of-function mutation of microRNA-140 in human skeletal dysplasia

Gain-of-function mutation of microRNA-140 in human skeletal dysplasia

MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression. Heterozygous loss-of-function point mutations of miRNA genes are associated with several human congenital disorders 1–5 , but neomorphic (gain-of-new-function) mutations in miRNAs due to nucleotide substitutions have not been...

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Bibliographic Details
Main Authors: Suzuki, Hiroshi I., Sharp, Phillip A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Subjects:
General Biochemistry, Genetics and Molecular Biology
General Medicine
Online Access:https://hdl.handle.net/1721.1/124510

Internet

https://hdl.handle.net/1721.1/124510

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