Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1

Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1

Bcl-2 family proteins control a decisive apoptotic event: mitochondrial outer membrane permeabilization (MOMP). To discover MOMP-regulating proteins, we expressed a library of intracellular single-chain variable fragments (scFvs) (“intrabodies”) and selected for those rescuing cells from apoptosis i...

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Bibliographic Details
Main Author: Vander Heiden, Matthew G.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020
Subjects:
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Neuroscience
General Agricultural and Biological Sciences
Online Access:https://hdl.handle.net/1721.1/124531

Internet

https://hdl.handle.net/1721.1/124531

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