VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells

VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells

There is an unmet need for new antimitotic drug combinations that target cancer-specific vulnerabilities. Based on our finding of elevated biomolecule oxidation in mitotically arrested cancer cells, we combined Plk1 inhibitors with TH588, an MTH1 inhibitor that prevents detoxification of oxidized nu...

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Bibliographic Details
Main Authors: Patterson, Jesse C., Joughin, Brian A., Whitman, Matthew A., Varmeh, Shohreh, Lauffenburger, Douglas A., Yaffe, Michael B.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/124625

Internet

https://hdl.handle.net/1721.1/124625

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