VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells

VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells

There is an unmet need for new antimitotic drug combinations that target cancer-specific vulnerabilities. Based on our finding of elevated biomolecule oxidation in mitotically arrested cancer cells, we combined Plk1 inhibitors with TH588, an MTH1 inhibitor that prevents detoxification of oxidized nu...

Full description

Bibliographic Details
Main Authors: Patterson, Jesse C., Joughin, Brian A., Whitman, Matthew A., Varmeh, Shohreh, Lauffenburger, Douglas A., Yaffe, Michael B.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/124625

Similar Items

Similar Items