Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT

Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT

DNA methylating agents are abundant in the environment and are sometimes used in cancer chemotherapy. They react with DNA to form methyl-DNA adducts and byproduct lesions that can be both toxic and mutagenic. Foremost among the mutagenic lesions is O6-methylguanine (m6G), which base pairs with thymi...

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Bibliographic Details
Main Authors: Thongararm, Pennapa, Fedeles, Bogdan I., Khumsubdee, Sakunchai, Armijo, Amanda L., Croy, Robert G., Essigmann, John M.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: American Chemical Society (ACS) 2020
Subjects:
Toxicology
General Medicine
Online Access:https://hdl.handle.net/1721.1/124796

Internet

https://hdl.handle.net/1721.1/124796

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